CY61032: Newer Asymmetric Reactions

CY61032
Course name	Newer Asymmetric Reactions
Offered by	Chemistry
Credits	3
L-T-P	3-0-0
Previous Year Grade Distribution
2 5 1 2 EX A B C D P F
Semester	Spring

Syllabus

Syllabus mentioned in ERP

Prerequisite : CY30103Principles of asymmetric reaction and synthesis; Kinetic resolution, Dynamic kinetic resolution (DKR) and autocatalytic reactions; Chemo-, regio-, diastereo- and enantio-controlled approaches; Chirality transfer and relay; Asymmetric inductions; Chiral pools, auxiliaries and templates; Asymmetric oxidations: Sharpless asymmetric epoxidation, dihydroxylation, aminohydroxylation, Jacobsen strategy, Sulphoxidation, Shi epoxidation. Asymmetric reduction reactions: Reduction of ketones, imines and olefins. Asymmetric C-C bond forming reaction: Simmon-Smith reaction, aldol reaction and alkylation based on Evans method, Mukayama aldol reaction, Shibasaki bi-metallic catalyst system; RAMP-SAMP based alkylation strategy, Meyers oxazoline and bis-lactam based methods; Michael reaction, Henry reaction (Nitro aldol), Baylis-Hillman-Morita reactions, Asymmetric allylation, Asymmetric cycloaddition reactions, Asymmetric hydroformylation. Asymmetric C-X bond formimg reaction: Asymmetric aziridination and regioselective ring opening of aziridines; Ring forming reactions. Organocatalysis: ï¡-functionalization of aldehyde and ketones, 1,4-conjugate addition (ï¢-functionalization and ï¡,ï¢-bifunctionalization of ï¡,ï¢-unsaturated carbonyl compounds).Books: Asymmetric Reactions and Processes in Chemistry: Ernest L. Eliel; Catalytic Asymmetric Synthesis: 2nd Ed., Iwao Ojima; Asymmetric Organocatalysis: From Biomimetic Concept to Applications in Asymmetric Synthesis: David MacMillan